Journal of Bioequivalence & Bioavailability

Yoshihiro Fukui

Publications

• Research Article
  Assessment of Ethnic Differences in the Pharmacokinetics and Pharmacodynamics of Valsartan
  Author(s): Gangadhar Sunkara, ChingMing Yeh, Monica Ligueros-Saylan, Hiroto Kawashita, Nozomu Koseki and Yoshihiro FukuiGangadhar Sunkara, ChingMing Yeh, Monica Ligueros-Saylan, Hiroto Kawashita, Nozomu Koseki and Yoshihiro Fukui
  
  Objective: To assess the potential ethnic differences in pharmacokinetics and pharmacodynamics of valsartan between Japanese and Caucasian subjects. Methods: This was an open-label, parallel-design study conducted in male Japanese (n=15) and Caucasian (n=15) subjects with similar age and body weight. All subjects received a single oral dose of 160 mg valsartan capsule, and the plasma levels of valsartan, aldosterone, and angiotensin II along with plasma renin activity (PRA) were determined at pre-set time intervals, post-dosing. Key findings: The time to reach peak plasma concentrations of valsartan (T max ) was in the range of 1–6 h in both groups. The mean C max of valsartan was 3.3 and 3.6 μg/ml; the mean plasma exposure (AUC 0- ∞ ) values were 23.0 and 23.8 μg.h/ml and the mean half-life (t 1/2 ) was 7.7 and 9.6 h in Japanese and Caucasian subjects, respectively... View More»
  DOI: 10.4172/jbb.1000043

  Abstract PDF