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Yong Chong
Yong Chong
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences,
3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582
Japan
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Research
Differences in the Hemagglutinin Amino Acids of Japanese and US Influenza A/H3N2 Viral Isolates and their Relationship with Vaccine Strain Differences
Author(s): Yong Chong and Hideyuki Ikematsu Yong Chong and Hideyuki Ikematsu
The effects of vaccination on the dynamics of influenza virus remain largely unknown. Different A/H3N2 vaccine strains were used in Japan and the United States (US) in the 2014-2015 season. To examine how different vaccine strains affect the selection of surviving variants, we compared hemagglutinin (HA) sequences in Japan with those in the US. A total of 85 A/H3N2 samples from 38 vaccinated and 47 unvaccinated Japanese patients (33 from the 2013-2014 and 52 from the 2014-2015 Japanese seasons) were isolated and genetically analyzed using a nextgeneration sequencer for comparison with 113 US isolates (30 from the 2013-2014 season and 83 from the 2014-2015 season) referenced from the GenBank database. HA1 amino acid (AA) differences between Japan and the US for the 2014-2015 vaccine strains were found at sites 128 (epitope B), 142 (A), 145 (A) and 198 (B). 145S and 198S in Japanese iso.. View More»
DOI: 10.4172/2157-7560.1000381