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Yoko Matsuda
Yoko Matsuda
Japan
Publications
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Review Article
The Roles and Molecular Mechanisms of Nestin Expression in Cancer with a Focus on Pancreatic Cancer
Author(s): Yoko Matsuda, Hisashi Yoshimura, Zenya Naito and Toshiyuki IshiwataYoko Matsuda, Hisashi Yoshimura, Zenya Naito and Toshiyuki Ishiwata
Nestin is a class VI intermediate filament protein that is expressed in a variety of stem and progenitor cells, including primitive neuroepithelial cells and pancreatic exocrine progenitor cells. Nestin expression is closely associated with rapidly proliferating progenitor cells during development and repair processes, and higher nestin expression levels correlate with poor prognosis in some cancers. Nestin regulates many molecules during cell processes in both normal and neoplastic tissues, and its transcription is regulated by enhancer regions in the second intron of the nestin gene that bind to SOX, Class III POU, and N-Myc. Nestin forms heterodimers with other intermediate filaments, with the class III intermediate filament protein vimentin being its main partner. Nestin/ vimentin copolymers provide an anchor for glucocorticoid receptors, regulate insulin-degrading enzyme, and pro.. View More»
DOI: 10.4172/2157-2518.S9-002