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Yerasi N
Yerasi N
India
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Research Article
Evaluation of Frog as an Animal Model to Study the Fraction of Oral Dose Absorbed in Humans
Author(s): Yerasi N, Vurimindi H and Devarakonda KYerasi N, Vurimindi H and Devarakonda K
To evaluate single pass intestinal perfusion method in frog for the prediction of absorption in man and also to evaluate the predictability of this model to classify drugs correctly under biopharmaceutical classification system (BCS). Single Pass Intestinal Perfusion (SPIP) studies were performed in Frogs of the species Rana tigrina using established method for rats with some modifications. Permeability was determined for each selected drug in 6 frogs and the results were presented as mean ± SD. Effective permeability coefficient (Peff) of 12 drugs was calculated. Permeability assessment of some carrier transported drugs which are also substrates for CYP enzymes was also done. Correlation of frog Peff with fraction of dose absorbed (FA) in man was done. Rank order comparison of permeabilities obtained in this study with two other absorption models (human jejunal perfusion, rat .. View More»
DOI: 10.4172/jbb.1000217