Journal of Bioequivalence & Bioavailability

Yasir Mehmood

Publications

• Research Article
  Ruta chalepensis L Considerable Action against Obesity or Hyperlipidemia in Body
  Author(s): Yasir Mehmood and Muhammad Imran AshrafYasir Mehmood and Muhammad Imran Ashraf
  
  Objective: This study was designed to estimate the efficacy of Ruta chalepensis L in falling the cholesterol levels in hypercholesterolemic rabbits. Materials and methods: Hypercholesteremia was induced in normal rabbits by adding 0.75 g cholesterol and 1.5 g bile salt in normal diet that were used for the experiments. Dried leaves and fruits powder of Ruta chalepensis L was administered as feed supplement at 5 g and 10 g dose levels to the hypercholesterolemic rabbits. Plasma and liver lipid profiles, fecal bile acid, hepatic HMG-CoA reductase, malondialdehyde, cholesterol and neutral sterols were estimated by using standard methods. Results: Feed supplementation with 5 g and 10 g of Ruta chalepensis L resulted in a significant decline in hepatic and plasma lipid profiles. The feed supplementation increased the HMG-CoA reductase activity and bile acid production in al.. View More»
  DOI: 10.4172/jbb.1000239

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