Journal of Carcinogenesis & Mutagenesis

Yang J

Publications

• Review Article
  Carcinoma Associated Fibroblast: A Paradoxical Role in Pancreatic Cancer Microenvironment and a Promising Target for Therapy
  Author(s): Yang J, Bail X and Liang T Yang J, Bail X and Liang T
  
  Pancreatic cancer is a grave malignancy showing an upward trend in morbidity and mortality during the recent decades. For reasons of late diagnosis, chemoresistance, low potential respectable rate and high post-operative recurrence rate, it has been the 6th most common cause of cancer death in China. As one of the most aggressive malignancies and the most common type of pancreatic cancer, pancreatic adenocarcinoma (PDAC) represents a significant therapeutic challenge. Conventional chemotherapeutic cytotoxic agents are proved to be with a poor survival benefit. Though the current first-line therapy FOLFIRINOX increased the median survival time compared with gemcitabine, it has been still unsatisfactory. Another direction enlighted by the treatement experience in other tumors is targeting certain molecules that participate in specific signaling pathways mediating cancer cell proliferati.. View More»
  DOI: 10.4172/2157-2518.1000271

  Abstract PDF