Pharmaceutica Analytica Acta

Yamada M

Publications

• Research Article
  Dietary Administration of Aloe Vera Gel Extract Inhibits Intestinal Polyp Formation in Min Mice Fed a High-Fat Diet
  Author(s): Chihara T, Shimpo K, Beppu H, Kaneko T, Higashiguchi T, Sonoda S, Tanaka M, Yamada M and Abe F Chihara T, Shimpo K, Beppu H, Kaneko T, Higashiguchi T, Sonoda S, Tanaka M, Yamada M and Abe F
  
  Objectives: Aloe vera gel extract (AVGE) was recently produced using a new procedure with supercritical carbon dioxide fluid. AVGE was proven safe in acute toxicity and subchronic toxicological tests, and was shown to contain five phytosterols (Aloe-sterols). AVGE may inhibit the accumulation of visceral fat due to the functions of Aloe-sterols, which may, in turn, contribute to preventing metabolic syndrome. A meta-analysis previously revealed that obesity was positively associated with colon cancer. Therefore, we examined the effects of the dietary administration of AVGE on intestinal polyp formation in Apc-deficient Min mice fed a high-fat diet (HFD). Methods: Male Min mice were divided into normal diet (ND), HFD, and AVGE groups. The ND group was fed an AIN-93G diet, the HFD group was given modified high-fat AIN-93G diets, and the AVGE group was fed HFD 0.0125% co.. View More»
  DOI: 10.4172/2153-2435.1000340

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