Journal of Nanomedicine & Nanotechnology

Xueqin Chen

Publications

• Research Article
  Multifuctional Nanofilm for Stimulating Bone Cell Attachment, Proliferation and Preventing Bacterial Colonization
  Author(s): Xueqin Chen, Zhengguang Sun, Bingbing Jiang and Cao LiXueqin Chen, Zhengguang Sun, Bingbing Jiang and Cao Li
  
  Osseointegration and infection prevention are of great importance for the long-term success of bone-in-contact implants. In this study, we developed multi-drug loaded polypeptide nanofilms on orthopedic implant models for potential enhanced osseointegration and improved infection prevention. RGD, a cell-adhesive ligand, transforming growth factor beta 1 (TGF-β1), a growth factor, and gentamicin, a common antibiotic, were successfully incorporated into one single polypeptide nanofilm. On one hand, the incorporation of Arg-Gly-Asp (RGD) within polypeptide nanofilms significantly improved osteoblast cell adhesion, proliferation, and viability. The incorporation of TGF-β1 led to enhanced osteoblast cell proliferation at day 5 and improved cell viability as well. However, polypeptide nanofilms with RGD or a combination of RGD and TGF also promoted bacterial growth after 2 days. O.. View More»
  DOI: 10.4172/2157-7439.1000482

  Abstract PDF