Journal of Nanomedicine & Nanotechnology

Wim de Jong

Publications

• Research Article
  Determination of Ti from TiO2 Nanoparticles in Biological Materials by Different ICP-MS Instruments: Method Validation and Applications
  Author(s): Yacine Nia, Sandrine Millour, Laurent Noël, Petra Krystek, Wim de Jong and Thierry Guérin Yacine Nia, Sandrine Millour, Laurent Noël, Petra Krystek, Wim de Jong and Thierry Guérin
  
  The accurate determination of nanoparticles (NPs) content in biological samples is of great interest for studying its potential impacts on health. This paper describes a method validation process for Ti determination from TiO2 NPs in biological matrixes using a closed-vessel microwave digestion with a mixture of 3 mL of HNO3 and 0.4 mL of HF and a detection by quadrupole inductively coupled plasma-mass spectrometry (Q-ICP-MS), in both standard and collision/ reaction cell (CCT) modes. As no suitable certified reference materials are available, several internal reference materials (IRMs) were prepared precisely and they were used for the optimisation and the analytical quality assurance of the method. Several criteria such as linearity, limits of quantification (LOQ), precision under repeatability conditions and intermediate preci.. View More»
  DOI: 10.4172/2157-7439.1000269

  Abstract PDF