Journal of Tropical Diseases & Public Health

Wilson R. Cunha

Publications

• Research Article
  Chemoprevention of Schistosomiasis: In vitro Antiparasitic Activity of Nineteen Plant-derived and Synthetic Simple Naphthoquinones and Naphthols against Schistosoma Mansoni Adult Worms
  Author(s): Lizandra G. Magalhães, G. Subba Rao, Ingrid A. O. Soares, Fernanda R. Badocco, Wilson R. Cunha, Vanderlei Rodrigues, and Govind J. KapadiaLizandra G. Magalhães, G. Subba Rao, Ingrid A. O. Soares, Fernanda R. Badocco, Wilson R. Cunha, Vanderlei Rodrigues, and Govind J. Kapadia
  
  Schistosomiasis, a debilitating disease dating back to ancient times, is currently endemic in 78 tropical and subtropical countries with 243 million people requiring treatment. Current treatment of schistosomiasis depends primarily on a single drug, praziquantel which is less effective against larval stage of the parasite and has potential for development of resistance. Thus, there is urgent need for development of new, effective and inexpensive antischistosomal drugs. Simple naphthoquinone (NAPQ) secondary metabolites in plants are known to act as phytotoxins in preventing bacterial, fungal and parasitic attacks. The present study reports antischistosomal activity of nineteen plant-derived and synthetic simple NAPQs and naphthols against Schistosoma mansoni adult worms under in vitro conditions. Four of the tested compounds met the WHO’s Special Program for Research an.. View More»
  DOI: 10.4172/2329-891X.1000146

  Abstract PDF