PMC/PubMed Indexed Articles
Indexed In
- Academic Journals Database
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- CiteFactor
- Scimago
- Ulrich's Periodicals Directory
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- MIAR
- University Grants Commission
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Werner FM
Werner FM
Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems (Lab. 14),
Salamanca
Spain
Publications
-
Short Communication
Extrapyramidal Symptoms in Patients Treated with Antipsychotic Drugs
Author(s): Werner FM and Coveñas RWerner FM and Coveñas R
Extrapyramidal symptoms are adverse effects of second-generation antipsychotic drugs which are generally used to treat schizophrenia and schizoaffective disorder. These adverse effects are due to the D2 receptor blockade. Neurotransmitter and neuropeptide alterations in the mesolimbic system and in the extrapyramidal system and the derived neural networks are described. M4 antagonists, GABAA agonists or NMDA antagonists can be used to treat the extrapyramidal symptoms because they improve the dopaminergic-cholinergic neurotransmitter imbalance in this neural system. Recently developed antipsychotic drugs such as aripiprazole and cariprazine cause less often and, to a lesser extent, extrapyramidal symptoms because they exert a partial agonism at the D2 receptor. .. View More»
DOI: 10.4172/jbb.1000333