Journal of Psychiatry

Wen-bo Wu

Publications

• Research Article
  Interaction between MicroRNA-7 and its Target Genes in Schizophrenia Patients
  Author(s): Jin Zhang, Guang-ya Zhang, Jin Xu, Wen-bo Wu, Xin-yang Sun, Li-yi Zhang and Shu-ya HeJin Zhang, Guang-ya Zhang, Jin Xu, Wen-bo Wu, Xin-yang Sun, Li-yi Zhang and Shu-ya He
  
  Objective: To verify interaction between miRNA-7 and its target genes, and explore its possible role in schizophrenia. Methods: The hippocampal neuron cells (HT22) in mice transfected by lentiviral vector with microRNA-7 interference and over-expression were cultured, and the microRNA expression profiling of HT22 target genes were measured by quantitative RT-PCR. Results: The expression of three genes (ERBB4, GABRA6, and GAD1) increased along with the low expression of miRNA-7, and decreased along with the over-expression of microRNA-7. Expression of GRIN2A gene increased along with microRNA-7 over-expression, and decreased when miRNA-7 was interfered. Conclusion: Expression of miRNA-7 may affect its target genes in schizophrenia patients, leading to alteration of neuronal morphology and function, which may play crucial roles in patho-mechanism of schizophrenia. Different from common .. View More»
  DOI: 10.4172/Psychiatry.1000235

  Abstract PDF