Journal of Stem Cell Research & Therapy

Wei W

Publications

• Research Article
  Glypican-3-Mediates Autophagy and Promotes Self-Renewal and Tumor Initiation of Hepatocellular Carcinoma Cells
  Author(s): Sun CK, Chua MS, Wei W and So SK Sun CK, Chua MS, Wei W and So SK
  
  Objective: Understanding the biological functions of cancer stem cells (CSCs) provide new avenues for therapeutic interventions, which is especially important in hepatocellular carcinoma (HCC), an often fatal malignancy. We aim to determine whether glypican-3 (GPC3), an over-expressed membrane protein in HCC, mediates CSC properties in HCC cells. Design: We determined the cell surface expression of GPC3 in HCC patients and HCC cell lines, and isolated GPC3-high/low sub-populations to study their abilities to self-renew. Additionally, we used HCC cell-based systems where GPC3 expression was either suppressed or induced, to validate the stem-like properties (spheroid formation, cell cycle progression, tumor initiation) that may be mediated by GPC3. Results: We observed highly specific cell surface expressi.. View More»
  DOI: 10.4172/2157-7633.1000229

  Abstract PDF