Journal of Stem Cell Research & Therapy

Wei Li

Publications

• Research Article
  Delivering Oxidation Resistance-1 (OXR1) to Mouse Kidney by Genetic Modified Mesenchymal Stem Cells Exhibited Enhanced Protection against Nephrotoxic Serum Induced Renal Injury and Lupus Nephritis
  Author(s): Yajuan Li, Wei Li, Chu Liu, Mei Yan, Indu Raman, Yong Du, Xiangdong Fang, Xin J. Zhou, Chandra Mohan and Quan-Zhen LiYajuan Li, Wei Li, Chu Liu, Mei Yan, Indu Raman, Yong Du, Xiangdong Fang, Xin J. Zhou, Chandra Mohan and Quan-Zhen Li
  
  Objective: To elucidate the role of oxidation resistance 1 (OXR1) gene Oxidative stress plays a pivotal role in pathogenesis of immune-mediated nephritis. Recently we identified oxidation resistance 1 (OXR1) is conventionally expressed in eukaryotes and has an ability to prevent oxidative damage caused by various oxidative stresses. Although the protective effect of OXR1 in immune-associated inflammatory response and oxidative damage is not clear and will be investigated in this study. Methods: We utilized mesenchymal stem cells (MSCs) as vehicles to carry OXR1 into the injured kidneys of nephritis model mice and investigated the influence of OXR1 on glomerulonephritis. Human OXR1 gene was integrated into genome of MSCs via lentiviral vector, and established hOXR1-MSC cell line which still maintains the differentiation property. 129/svj mice with anti-glomerular basement membrane (GBM.. View More»
  DOI: 10.4172/2157-7633.1000231

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