Journal of Vaccines & Vaccination

Watts DM

Publications

• Research Article
  Safety and Immunogenicity of Rift Valley Fever MP-12 and a Novel arMP-12?NSm21/384 Recombinant Vaccine Candidate in Native Breed of Black Head Sheep (Ovis aries) from Tanzania
  Author(s): Adamson EK, Nyundo S, Rowland J, Palermo PM, Matiko MK, Bettinger GE, Wambura P, Morrill JC and Watts DMAdamson EK, Nyundo S, Rowland J, Palermo PM, Matiko MK, Bettinger GE, Wambura P, Morrill JC and Watts DM
  
  Objective: Rift Valley fever (RVF) is a mosquito-borne zoonotic viral disease that affects humans and ruminants in Africa and the Arabian Peninsula. Efforts to develop effective vaccines have had limited success. Therefore, the aim of this study was to evaluate the safety and immunogenicity of RVF MP-12, and arMP-12ΔNSm21/384 vaccine candidates in sheep. Methods: One group of 6 sheep was vaccinated intramuscularly (IM) each with one ml of 1×105 PFU/ml of the RVF MP-12 and 9 sheep were inoculated IM each with one ml of the arMP-12ΔNSm21/384 vaccine candidate, and two control sheep received one ml each of only Eagle's Minimum Essential Medium. Blood samples obtained on days 14 and 0 before vaccination and on days 3, 4, and 5 post vaccination (PV) were tested for RVFV in Vero cells and by RT PCR assay, and samples collecte.. View More»
  DOI: 10.4172/2157-7560.1000394

  Abstract PDF