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Walla Saeed Eltahir Saeed
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Immune Response Modifying Effects of Bee Venom Protein [Melittin]/Autoclaved L. donovani complex in CD1 Mice: The Search for New Vaccine Adjuvants
Author(s): Walla Saeed Eltahir Saeed and Eltahir Awad Gasim Khalil Walla Saeed Eltahir Saeed and Eltahir Awad Gasim Khalil
Visceral leishmaniasis (VL) is a major cause of morbidity/mortality in remote areas of East Africa. Vaccines for VL can provide an effective control measure to help control/eliminate this fatal disease. To date there is no effective anti-leishmanial vaccine. There is an urgent need to develop effective adjuvants-potentiated anti-leishmanial vaccines. Bee venom protein, melittin is a natural substance that is reported to boost the immune system providing rapid non–specific defense against infections. This study aimed to determine the immune response modifying effects of melittin and melittin/Autoclaved Leishmania donovani [ALD] complex on Swiss CD1 Albino mice. One hundred and eighty five CD1 mice were divided into control [no vaccine] and vaccine groups [3 doses of ALD alone, melittin, melittin/ALD mixture or melittin-adsorbed ALD]. Whole blood cytokines levels [IL-10, .. View More»
DOI: 10.4172/2157-7560.1000372