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Walaa A Abdelazem
Walaa A Abdelazem
Egypt
Publications
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Research Article
Urinary Glycosaminoglycans in Asthmatic Children in Relation to Disease Control by Inhaled Corticosteroids
Author(s): Deraz TE, Terez B Kamel, Enas S Nabih and Walaa A Abdelazem Deraz TE, Terez B Kamel, Enas S Nabih and Walaa A Abdelazem
Background: Chronic inflammation and airway remodeling are important characteristics of human asthma. Increased deposition of extracellular matrix in the airway wall contributes to airway remodeling in asthmatics. Glycosaminoglycans (GAGs) are polysaccharides attached to a protein core to form proteoglycans, a component of the ECM. Objective and method: In this study, urinary GAGs levels of asthmatic children were investigated in relation to disease control and medication. Sixty asthmatic children (48 boys, 12 girls), aged 4-14 years, were recruited in the study; twenty were controlled asthma on inhaled fluticasone, twenty were uncontrolled asthma due to incompliance on inhaled fluticasone and twenty uncontrolled who were only on relief medications. Age and gender matched 20 healthy controls were also included. GAGs were precipitated from collected early morning urine samples, isolate.. View More»
DOI: 10.4172/2155-6121.1000217