Journal of Carcinogenesis & Mutagenesis

Wai-Yuan Tan

Publications

• Review Article
  A New Stochastic Model of Retinoblastoma Involving both Hereditary and Non-hereditary Cancer Cases
  Author(s): Wai-Yuan Tan and Hong Zhou Wai-Yuan Tan and Hong Zhou
  
  Background and purpose: Retinoblastoma is initiated by the mutation or loss or inactivation of the retinoblastoma gene (the Rb gene) in chromosome 13q14. Further, both the germline cells (eggs and sperm) generating the individuals may carry a mutant allele of the Rb gene so that individuals may carry both mutants in the Rb locus at the embryo stage in which case cancer tumor may develop at or before birth. Recent molecular studies have also shown that besides the abrogation of cell dierentiation by the inactivation of the Rb locus, the apoptosis mechanism needs also to be inhibited or abrogated for the generation of retinoblastoma tumor. The purpose of this paper is to develop new stochastic and statistical models for retinoblastoma to incorporate these biological findings. Results: Based on recent biological studies, in this paper we have d.. View More»
  DOI: 10.4172/2157-2518.1000117

  Abstract PDF