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Waghmare Somnath
Waghmare Somnath
India
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Research Article
Identification of Antigenic Determinants, Solvent Accessibility and MHC Binders of Peb1a from Campylobacter jejuni
Author(s): Sherkhane AS, Waghmare Somnath and Gomase VS Sherkhane AS, Waghmare Somnath and Gomase VS
Campylobacter jejuni is a foodborne, highly mutable in response to antibiotic, pathogen causing gastroenteritis in humans. In this study we summarize the potency of Peb1a from Campylobacter jejuni with 259 amino acids. Antigenic peptides of Peb1a from Campylobacter jejuni are most suitable for subunit vaccine development because with single epitope, the immune response can be generated in large population. In this research, we used PSSM and SVM algorithms for the prediction of MHC class I & II binding peptide, antigenicity, Solvent accessibility, polar and nonpolar residue to analyses the regions that are likely exposed on the surface of proteins which are potentially antigenic that allows potential drug targets to identify active sites against infection as well as to design effective drug to treat it. .. View More»
DOI: 10.4172/2155-9597.1000193