PMC/PubMed Indexed Articles
Indexed In
- Academic Journals Database
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- CiteFactor
- Scimago
- Ulrich's Periodicals Directory
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- MIAR
- University Grants Commission
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Waggas AS
Waggas AS
Slovak republic
Publications
-
Research Article
Brain Biogenic Monoamines in Relation to Brain Histopathology and Plasma Glutathione Shuttle in Rat after Exposure to Sea Anemone Gyrostoma helianthus Extract
Author(s): Al-Hazmi MA, Gomma MN, Waggas AS and Rawi SMAl-Hazmi MA, Gomma MN, Waggas AS and Rawi SM
The extract of sea anemone Gyrostoma helianthus (Cnidaria, Anthozoa) has been reported as a source of neuroactive compounds. The current study was designed to explore biogenic monoamine effects of sea anemone crude extract in relation to histopathological changes in brain areas and plasma glutathione shuttling. Mouse bioassays were used to determine the dose response curve and behavioral neurotoxicity. Loss of balance, opaque eyes, tonic convulsions, paralysis, muscle flexing, and exophthalmia were the major behavioral changes observed. The LD50 in mice was identified as 29 mg/kg body weight after IP injection, which is calculated to be 20.3 mg/kg body weight in rats using a conversion table. Serotonin, dopamine, and norepinephrine were significantly increased in the cerebral cortex, cerebellum and pons plus medulla oblongata in rats in our 3-day study after a single IP injection of &.. View More»
DOI: 10.4172/jbb.1000208