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Wadhwani AD
Wadhwani AD
India
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Research Article
Targeting Efficacy of Simvastatin for Hormone-Dependent Carcinomas through Solid Lipid Nanoparticles
Author(s): Dasam U, Jawahar Natarajan, Karri VVSR, Wadhwani AD, Antony J and Jeyaprakash MRDasam U, Jawahar Natarajan, Karri VVSR, Wadhwani AD, Antony J and Jeyaprakash MR
Folate conjugated Simvastatin loaded Solid lipid nanoparticles (SIM-SLNs) were constructed after the preformulation studies such as Differential calorie metry (DSC), Fourier transform infrared spectroscopy (FTIR) and partition coefficient studies. SIM-SLNs were evaluated in terms of particles size, zeta potential, drug encapsulation, and drug release. The cytotoxicity of the SLNs was evaluated on MCF-7 Human Breast Carcinoma cells (MCF-7 cells) by MTT assay. In vivo pharmacokinetic parameters and Bio-distribution were observed in Wistar rats. The particle size of SIM-SLNs (F6) was 177.4 nm with a zeta potential of -5.16 mV. The entrapment efficiency and drug loading was found to be higher in SIM-SLNs. SLN formulation released the drug in sustained manner over a period of 24 hours. Various kinetic models were fitted and it was observed that Higuchi’s model was the best fit model... View More»
DOI: 10.4172/2157-7439.1000412