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Vikash Kumar
Vikash Kumar
India
Publications
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Research Article
Taguchi and Quadratic via Chromogenic Design Methodology: A Better to Best Estimation Process (Tizanidine Hcl) Bulk/Pharmaceutical
Author(s): Vikash Kumar, Kamal Dua, Sushila Rathee and Permender RatheeVikash Kumar, Kamal Dua, Sushila Rathee and Permender Rathee
A finest quantitative responsive with reproducible best method was developed using designed array (Taguchi) and Quadratic design methodology (RSM) chromomeric spectrophotometric estimation of bulk as well as pharmaceutical (Tizanidine HCl). Initially (Taguchi), orthogonal array design was applied to find significant variables as well as optimum (better) levels. By response surface (central composite; quadratic) methodology were used to ascertain optimum to optimized ?Better to Best? and studied values of variables (independent significant; X1=PDAB=chromogenic reagent; FeCl3=X2=ferric ion at optimum levels with drug constant=X3) responses (dependent Y1=absorbance) models at positive and negative (+1/-1 optimum spaces) levels. More-more, designed independent factorial levels ?better to best? surface models (3D) and its polynomial (2nd order) equation was predicted the finest level which fu.. View More»
DOI: 10.4172/2153-2435.1000319