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Vikas Bommasane
Vikas Bommasane
India
Publications
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Review Article
Review on Nitric Oxide, Carbon Monoxide and Antisense Based Therapy towards Treatment of Restenosis
Author(s): Prathibha Ramadugu, Kanaka Latha Alikatte, Narendar Dhudipala and Vikas BommasanePrathibha Ramadugu, Kanaka Latha Alikatte, Narendar Dhudipala and Vikas Bommasane
Balloon angioplasty has shown tremendous improvement in the treatment of atherosclerosis, but arterial renarrowing (restenosis) exists despite the benefits of intravascular devices called stents. Nitric Oxide (NO), carbon monoxide (CO) and Antisense therapy is some of the new potential treatment modalities. NO deficiency is associated with several vascular occlusive diseases, since NO regulates diverse aspects of blood vessel functions. More restricted human studies and several preclinical studies suggest that, NO supplement may solve the restenosis problem, although the data do not conclusively demonstrate this effect. CO, similar to NO, inhibits vascular smooth muscle cells (VSCM) proliferation and in turn relaxes blood vessels and inhibits platelet aggregation. Thus it is recently suggested that inhaling CO could address the restenosis problem. Recent a.. View More»
DOI: 10.4172/jbb.1000268