Vidal TR
Brazil
Research Article
Alpha-Linolenic Acid Supplementation is Associated with Changes in Inflammatory Markers and Endoplasmic Reticulum Stress in Diabetic Rats
Author(s): Ferraz RC, Foss-Freitas MC, Vidal TR, Griffo TN, Gonçalves NB, Jordao Jr AA and Foss MC
Ferraz RC, Foss-Freitas MC, Vidal TR, Griffo TN, Gonçalves NB, Jordao Jr AA and Foss MC
Background: The aim of this study was to evaluate the effects of α-linolenic acid (ALA) supplementation on inflammation and endoplasmic reticulum stress (ERS) in streptozotocin induced diabetic rats.
Methods: We studied 40 Wistar rats divided into four groups: control, control+ALA, diabetes and diabetes+ALA. The +ALA groups received supplementation of 3 g of ALA from flaxseed, daily for a period of 8 weeks. Measurements of blood glucose levels, serum insulin, lipid profile, serum cytokines (TNF-α, IL-6 and INF-γ) and body weight were performed before and after the ALA supplementation. Protein expression of AKT, IRE1-α, XBP-1, BIP, HSP-70, HSP-90, TNF-α and CHOP were evaluated in liver tissue.
Results: The diabetes+ALA group had lower liver and greater epidydimal adipose tissue weight in rela.. View More»
DOI:
10.4172/2157-7110.1000720