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Vemula SK
Vemula SK
India
Publications
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Research Article
Formulation and Pharmacokinetics of Ketorolac Tromethamine Floating Compression Coated Mini-Tablets
Author(s): Vemula SK, Venisetty RK and Veerareddy PR Vemula SK, Venisetty RK and Veerareddy PR
Present research is intended to develop the Ketorolac Tromethamine (KTM) effervescent floating mini-tablets using compression coating method. Mini-tablets have the advantages of both tablets and multiparticulate formulations such as pellets. The main principle of floating mini-tablets can be applied to decrease the irritant effect of KTM on the stomach by avoiding the direct contact with the gastric mucosa and obtaining a low dosage for prolonged periods. KTM mini-tablets were prepared using 4 mm round flat punches and compression coated with hydroxypropyl methylcellulose and effervescent mixture. The prepared tablets were evaluated for weight variation, thickness, friability, hardness, drug content, in vitro buoyancy and in vitro release and the best formulation was subjected to further in vivo examination. The prepared mini-tablets exhibited satisfactory p.. View More»
DOI: 10.4172/jbb.1000351