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Varo N
Varo N
Pamplona
Spain
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Research Article
Serum Osteoprotegerin is Diminished in the Polycystic Ovary Syndrome and Associated with Insulin Resistance
Author(s): Pérez de Ciriza C and Varo N Pérez de Ciriza C and Varo N
Abstract Introduction: The polycystic ovary syndrome (PCOS) is a common endocrine disorder of reproductive age characterized by androgen excess and anovulation. PCOS is associated with insulin resistance (IR) and cardiovascular risk factors. Osteoprotegerin (OPG), an osteoclastogenesis inhibitor, has recently been related to metabolic and vascular disorders suggesting a possible link between OPG, PCOS and IR. Objectives: To determine the association between OPG and IR in women suffering from PCOS and to review the existing literature. Materials and Methods: Informed, written consent was obtained from 30 premenopausal women classified as PCOS (n = 13) or controls (n = 17) according to the Rotterdam criteria. Obese patients were excluded from the study. Biochemical analyses were performed .. View More»
DOI: 10.4172/2161-1009.1000247