Journal of Nanomedicine & Nanotechnology

Van Winkle LS

Publications

• Research Article
  Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver
  Author(s): Holland NA, Becak DP, Shannahan JH, Brown JM, Carratt SA, Van Winkle LS, Pinkerton KE, Wang CM, Munusamy P, Baer DR, Sumner SJ, Fennell TR, Lust RM and Wingard CJHolland NA, Becak DP, Shannahan JH, Brown JM, Carratt SA, Van Winkle LS, Pinkerton KE, Wang CM, Munusamy P, Baer DR, Sumner SJ, Fennell TR, Lust RM and Wingard CJ
  
  Background: Silver nanoparticles (AgNP) have garnered much interest due to their antimicrobial properties, becoming one of the most utilized nano-scale materials. However, any potential evocable cardiovascular injury associated with exposure has not been reported to date. We have previously demonstrated expansion of myocardial infarction after intratracheal (IT) instillation of carbon-based nanomaterials. We hypothesized pulmonary exposure to Ag core AgNP induces a measureable increase in circulating cytokines, expansion of cardiac ischemia-reperfusion (I/R) injury and is associated with depressed coronary constrictor and relaxation responses. Secondarily, we addressed the potential contribution of silver ion release on AgNP toxicity. Methods: Male Sprague-Dawley rats were exposed to 200 μl of 1 mg/ml of 20 nm citrat.. View More»
  DOI: 10.4172/2157-7439.S6-006

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