Pharmaceutica Analytica Acta

Tsuyoshi Sugiyama

Publications

• Research Article
  Agarwood (Aquilaria Crassna) Extracts Decrease High-protein High-fat Diet-induced Intestinal Putrefaction Toxins in Mice
  Author(s): Mamoru Kakino, Tsuyoshi Sugiyama, Hitomi Kunieda, Shigemi Tazawa, Hiroe Maruyama, Kazuhiro Tsuruma, Yoko Araki, Masamitsu Shimazawa, Kenji Ichihara, Hiroshi Mori and Hideaki HaraMamoru Kakino, Tsuyoshi Sugiyama, Hitomi Kunieda, Shigemi Tazawa, Hiroe Maruyama, Kazuhiro Tsuruma, Yoko Araki, Masamitsu Shimazawa, Kenji Ichihara, Hiroshi Mori and Hideaki Hara
  
  Agarwood (Aquilaria spp.) is famous for its aromatic resin, but its leaves are also prized as a healthy tea in South East Asia. Previously, we reported that agarwood extract (Aquilaria sinensis and Aquilaria crassna) shows laxative effect via acetylcholine receptors in constipation model mice and rats. In the present study, we investigated the effects of agarwood (Aquilaria crassna) on intestinal toxins, such as indole derivatives and ammonium to investigate the enteral environment. Male mice received regimens of three types of food, CE-7 (normal diet), CE-2 (high-protein normal diet), and Quick Fat (high-protein high-fat diet). Extracts of agarwood (water extract of agarwood: WEA and ethanol extract of agarwood: EEA) were orally administered once daily for a week. We measured the contents of indole derivatives and ammonium in feces and also examined the Minimum Inhibitory Concentrati.. View More»
  DOI: 10.4172/2153-2435.1000152

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