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Toshio Niwa
Toshio Niwa
Department of Human Health and Nutrition, Shokei Gakuin University,
Japan
Publications
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Short Communication
Cleavage of Methyl Ethers by O-Desmethylangolensin-Producing Clostridium Strain SY8519
Author(s): Toshio Niwa, Shin-Ichiro Yokoyama, Yuika Kawada, Tohru Suzuki and Toshihiko OsawaToshio Niwa, Shin-Ichiro Yokoyama, Yuika Kawada, Tohru Suzuki and Toshihiko Osawa
We previously isolated an O-desmethylangolensin (O-DMA)-producing bacterium, Clostridium rRNA cluster XIVa strain SY8519. We studied the metabolism of soy isoflavonoids by strain SY8519 and found that the bacterium attenuated the activity of isoflavonoids by “decomposition”. In this study, the O-methyl derivatives of isoflavones formononetin and biochanin A were fed to the bacterium. Formononetin and biochanin A were metabolized to O-DMA and 2-(4-hydroxyphenyl) propionic acid, respectively, which are the products of the original isoflavones. We could detect daidzein as an intermediate in the production of O-DMA from formononetin by time course analysis of the culture medium. Therefore, strain SY8519 can cleave the O-methyl ethers of isoflavones. We then examined the demethylation of O-methyl derivatives of gallic acid methyl ester by strain SY8519. The metabolite was almos.. View More»
DOI: 10.4172/1948-5948.1000221