Journal of Microbial & Biochemical Technology

Toshiharu Shirai

Publications

• Research Article
  Temporal Attenuation of Iodine Content and its Effect on the Antibacterial Activity of Iodine-Supported Titanium Implants
  Author(s): Takashi Kato, Toshiharu Shirai, Norio Yamamoto, Hideji Nishida, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kaori Ohtani and Hiroyuki TsuchiyaTakashi Kato, Toshiharu Shirai, Norio Yamamoto, Hideji Nishida, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kaori Ohtani and Hiroyuki Tsuchiya
  
  Infections related to orthopedic implants often require prolonged therapy and complex interventions; accordingly, the development of implants with a low risk of infection is a high priority. Iodine-supported titanium implants with antibacterial activity are safe and effective for prophylaxis against implant-related infections. However, temporal changes in the iodine content of implants and the effects on antibacterial activity have not been investigated. In vitro antibacterial activity against Staphylococcus aureus and Escherichia coli was investigated using implants with various iodine contents (0%, 20%, 50%, 60%, and 100%, where 100% corresponds to 13 μg/cm2 iodine based on current implants in clinical use). Temporal changes in iodine for 10–12 μg/cm2 iodine-supplemented titanium implants were also investigated in vitro and in vivo using rabbit models (subcutaneous soft .. View More»
  DOI: 10.4172/1948-5948.1000298

  Abstract PDF