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Tomohiro Matsuyama
Tomohiro Matsuyama
Japan
Publications
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Research Article
Expression Patterns and Phenotypic Changes Regarding Stemness in Brain Pericytes in Health and Disease
Author(s): Akiko Nakano-Doi, Takayuki Nakagomi, Rika Sakuma, Ai Takahashi, Yasue Tanaka, Miki Kawamura and Tomohiro Matsuyama Akiko Nakano-Doi, Takayuki Nakagomi, Rika Sakuma, Ai Takahashi, Yasue Tanaka, Miki Kawamura and Tomohiro Matsuyama
Objective: Brain pericytes (PCs), which exist near endothelial cells, function in processes including maintenance of the blood–brain barrier and as stem cells. However, the relationship between expression patterns and phenotypic changes regarding stemness in brain PCs remains unclear. Thus, we investigated the properties of brain PCs in healthy and diseased mice. Methods: We examined the expression of representative pericytic markers, such as neuron-glial antigen 2 (NG2) and alpha smooth muscle actin (αSMA), and of the stem cell marker Nestin, in developing and pathologic mouse brains. Results: Brain PCs expressed NG2 and αSMA during the embryonic and postnatal stages of development, but rarely during adulthood. Although brain PCs exhibited Nestin expression durin.. View More»
DOI: 10.4172/2157-7633.1000332