Journal of Stem Cell Research & Therapy

Tom Mariën

Publications

• Research Article
  The Influence of Allogenic Mesenchymal Stem Cells on the Hematological Status of Horses
  Author(s): Sarah Broeckx, Rudy Forier, Tom Mariën, Marc Suls, Vuk Savkovic, Alfredo Franco-Obregón, Luc Duchateau and Jan H Spaas Sarah Broeckx, Rudy Forier, Tom Mariën, Marc Suls, Vuk Savkovic, Alfredo Franco-Obregón, Luc Duchateau and Jan H Spaas
  
  Background: It has been reported that mesenchymal stem cells (MSCs) have homing capacities after an intravenous injection and immuno modulating effects in vitro. However, there are no reports on their effect on the animal’s hematological status. Methods: Therefore, MSCs were isolated and characterized from a 4-years-old horse donor after having tested his blood on a wide range of transmittable diseases. Then, 6 horses (13- to 15-years-old) received a single injection into the jugular vein: 3 with MSCs and 3 with the carrier fluid consisting of DMEM and 10% of DMSO. Multiple blood samples were taken at different time points at the same time of the day: before the intravenous MSC (Veno-Cell®) injection ( T0) and 1 day (T1), 1 week (T2), 3 weeks (T3) and 2 months (T4) after the treatment. Results: In the control group no considerable changes were noticed over t.. View More»
  DOI: 10.4172/2157-7633.1000136

  Abstract PDF