Advances in Pharmacoepidemiology and Drug Safety

Tobe EH

Publications

• Case Report
  Modafinil Enhances Two-Year Outcome from Monoamine Oxidase Inhibitor Therapy in 3 Patients with Treatment-Resistant Depression
  Author(s): Tobe EH Tobe EH
  
  Background: Modafinil has complex, and as yet unclear, pharmacodynamics mechanisms. The prescribing of modafinil to augment monoamine oxidase inhibitor (MAOI) therapy was investigated for 3 patients with major depressive disorder determined to be treatment-resistant depression. Methods: As a retrospective report from a private psychiatry practice, 2 men and 1 woman with major depressive disorder, aged from 55 to 60 years, were evaluated and treated. All patients met criteria for treatment-resistant depression, with failure of 3 or more trials of medication with augmentation; one patient failed electroconvulsive therapy and vagal nerve stimulation. All patients had reported feeling some improvement before the addition of modafinil to existing MAOI therapy. However, immobilizing exhaustion in the 2 male patients and fatigue in the female patient impaired daily.. View More»
  DOI: 10.4172/2167-1052.1000189

  Abstract PDF