Journal of Blood Disorders & Transfusion

Timori NH

Publications

• Research Article
  Quality Control of Platelets Concentrates; an In Vitro Fate Prediction Model System of PCs Transfusion
  Author(s): Timori NH and Badlou BA Timori NH and Badlou BA
  
  Introduction: We previously described that metabolic resting preserves old and cold platelets (PLTs) concentrates (PCs). In Badlou et al. 2006 we have established that P-selectin involved as an intermediate in binding, and the combination of PS exposure with (-out) changes in GPIb in phagocytosis of PCs. Using a standard threshold over the interaction between donors PLTs and patient’s phagocytes might increase success of transfusion, and decrease side effects, pretransfusion. The aim of this study is to introduce a novel method, which could be used as an in-vitro prediction model system to envisage PCs fate, posttransfusion. Materials and Methods: Human PCs were stored for different periods to obtain a wide range of surface expressed P-selectin and-PS exposure. The quantitative change in GPIb was deduced from decreased bindin.. View More»
  DOI: 10.4172/2155-9864.1000275

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