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Tima Thomas
Tima Thomas
Tanzania
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Research Article
Size Effects of Nanocomplex on Tumor Associated Macrophages Targeted Delivery for Glioma
Author(s): Lei Zou, Alejandro Macias sustaita, Tima Thomas, Lihn Do, Juan Rodriguez and Huanyu DouLei Zou, Alejandro Macias sustaita, Tima Thomas, Lihn Do, Juan Rodriguez and Huanyu Dou
The size of functional nanocomplexes, which targets the brain tumor associated macrophages nanocomplex plays a very important role in their interaction with cells involving uptake, release and targeting selectivity. The size effects of nanocomplex on cell-based targeted delivery were studied to investigate if this phenomenon can be employed to combine the targeting peptide to provide a selective tumor associated macrophages targeted delivery system for anti-glioma therapy. Paclitaxel (PTX) was loaded into a core-shell structure of nanocomplex (PTX-Nanocomplex). Three different sizes of PTX-nanocomplex were prepared through nanoprecipitation. Rabies virus glycoprotein (RVG) peptide was conjugated to PTX-nanocomplex to form RVG-PTX-nanocomplex. Uptake, release, transportation and anti-glioma activities were studied in in vitro by using bone marrow derived ma.. View More»
DOI: 10.4172/2157-7439.1000339