Cardiovascular Pharmacology: Open Access

Tian J

Publications

• Review Article
  Reducing Cardiac Fibrosis: Na/K-ATPase Signaling Complex as a Novel Target
  Author(s): Fan X, Xie J and Tian J*Fan X, Xie J and Tian J*
  
  Cardiac fibrosis is a common pathological process in cardiac disease and may lead to heart failure. It can also cause sudden death even in those without cardiac symptoms. Tissue fibrosis can be categorized into two categories: replacement fibrosis (also called reparative fibrosis) and reactive fibrosis. In replacement fibrosis, infiltration of inflammatory cells and accumulation of Extracellular Matrix (ECM) proteins are the initial steps in forming scarlike fibrotic tissue after acute cardiac injury and cardiac cell necrosis. Reactive fibrosis can be formed in response to hormonal change and pressure or volume overload. Experimental studies in animals have identified important pathways such as the Renin-Angiotensin-Aldosterone System (RAAS) and the endothelin pathway that contribute to fibrosis formation. Despite the fact that clinical trials using RAAS inhibitors as therapies for re.. View More»
  DOI: 10.4172/2329-6607.1000204

  Abstract PDF