Journal of Nanomedicine & Nanotechnology

Thomas L Moore

Publications

• Research Article
  Polymer-Coated Hydroxyapatite Nanoparticles for the Delivery of Statins
  Author(s): Thomas L Moore, Ann-Sofie Schreurs, Rachel A Morrison, Erika K Jelen, Joachim Loo, Ruth K Globus and Frank AlexisThomas L Moore, Ann-Sofie Schreurs, Rachel A Morrison, Erika K Jelen, Joachim Loo, Ruth K Globus and Frank Alexis
  
  Statin drugs have been previously reported to increase the activity of osteoblasts, and are being investigated to treat low bone density pathologies. A controlled release nanoparticle drug delivery system may be used to prolong the exposure of osteoblasts to statin. Furthermore, nano-hydroxyapatite (nHA) has known osteoconductive and osteoinductive properties. The success of nanoparticle drug delivery systems is associated with safety, stability, biodegradability, and pharmacological parameters. nHA have been used as gene and drug delivery vehicles, however in vivo studies have shown that nHA aggregate, accumulate in the lungs, and impede the function of pulmonary surfactant. To address some of these challenges, we present a nHA coated with the biodegradable co-polymer poly(glycolide)- poly(ethylene glycol) (PGA-PEG). PGA coating thickness could be precisely tuned by surface initiated.. View More»
  DOI: 10.4172/2157-7439.1000237

  Abstract PDF