Cardiovascular Pharmacology: Open Access

Thierno Madjou Bah

Publications

• Research Article
  The Sphingosine-1-Phosphate Receptor Agonist FTY720 Increases Heart Rate Variability in Isolated Murine Ischemic Heart Model
  Author(s): Emmanuel E Egom, Thierno Madjou Bah and Ming LeiEmmanuel E Egom, Thierno Madjou Bah and Ming Lei
  
  Despite considerable improvements in the management of hypertension, only half of adults with hypertension have their blood pressure under control. Uncontrolled hypertension may contribute to the development of left ventricular hypertrophy-induced myocardial ischemia. Accumulating evidence also suggests that hypertension may lead to lower heart rate variability (HRV), which is associated with an increased risk of cardiovascular disease. This forms the basis for the hypothesis that interventions aiming at raising HRV and reducing ischemia-induced injury in hypertensive patients, especially after AMI, may reduce the risk of cardiac events and mortality. In experiments reported here, we investigated the effects of the sphingosine-1-phosphate receptor agonist FTY720 on HRV in isolated, denervated murine ischaemic hearts. Our results demonstrated the presence of one major concentration of .. View More»
  DOI: 10.4172/2329-6607.1000107

  Abstract PDF