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Teresa Coccini
Teresa Coccini
IRCCS Maugeri Foundation, Medical Institute of Pavia, Laboratory of Clinical Toxicology,
Via Maugeri, 10 - 27100 Pavia
Italy
Publications
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Research Article
Gene Expression Changes in Rat Liver and Testes after Lung Instillation of a Low Dose of Silver Nanoparticles
Author(s): Teresa Coccini, Rosalba Gornati, Federica Rossi, Elena Signoretto, Isabella Vanetti, Giovanni Bernardini and Luigi ManzoTeresa Coccini, Rosalba Gornati, Federica Rossi, Elena Signoretto, Isabella Vanetti, Giovanni Bernardini and Luigi Manzo
The expression profile of genes involved in oxidative stress, metal toxicity, apoptosis/cell cycle, and protein folding was investigated in liver and testis of Sprague-Dawley rats at different time intervals after i.t. instillation of AgNP (20 nm, 50 μg/rat). At 7 days, selective changes in the expression of genes encoding oxidative stress-related enzymes, namely Gpx1, SOD, FMO2 and GAPDH were observed in hepatic and testicular tissues. Other genes implicated in oxidative stress (Txnrd1, Gss, Gsr), metal toxicity (Mt1), apoptosis/cell cycle (casp3, p53), and protein-folding processes (Hsp70) were not modified. Gene expression was modulated by AgNPs in a tissue- and time-dependent manner. In particular, SOD was up-regulated in both tissues, but significant Gpx1, FMO2, and GAPDH overexpression was seen i.. View More»
DOI: 10.4172/2157-7439.1000227