Cardiovascular Pharmacology: Open Access

Tatsuya Noguchi

Publications

• Research Article
  Donepezil, Therapeutic Acetylcholinesterase Inhibitor, Prevents the Progression of Ventricular Dysfunction by Promoting Myocardial Glucose Utilization in Rat Model of Chronic Heart Failure Following Myocardial Infarction
  Author(s): Mikihiko Arikawa, Yoshihiko Kakinuma, Tatsuya Noguchi and Takayuki SatoMikihiko Arikawa, Yoshihiko Kakinuma, Tatsuya Noguchi and Takayuki Sato
  
  Background: Donepezil, an acetylcholinesterase inhibitor, is reported to prevent cardiac pumping dysfunction in rats with chronic heart failure (CHF). Because energy substrate switching is a potential therapeutic target for the pharmacological treatment of CHF, we investigated the effect of donepezil on cardiac energy metabolism. Methods and Results: After induction of myocardial infarction (MI), rats were assigned to untreated and donepezil-treated (DPZ) groups. At the chronic phase of MI, resting heart rate was comparable between the untreated and DPZ groups. Nevertheless, left ventricular contractility evaluated in Langendorff-perfused hearts was significantly improved by donepezil treatment. At the same time point, the expression level of cardiac glucose transporter (GLUT) was significantly higher in the DPZ group than in the untreated gro.. View More»
  DOI: 10.4172/2329-6607.1000121

  Abstract PDF