Journal of Vascular Medicine & Surgery

Taro Mizutani

Publications

• Research Article
  Landiolol Hydrochloride Normalizes Diminished Levels of Cardiac Vascular Endothelial Growth Factor (VEGF) Signaling System Components in Lipopolysaccharide-Induced Sepsis Independent of Inflammatory Markers
  Author(s): Yoshimoto Seki, Subrina Jesmin, Majedul Islam, Yoshiyasu Ogura, Masami Oki, Nobutake Shimojo, Tanzila Khatun, Hideaki Sakuramoto, Satoru Kawano and Taro MizutaniYoshimoto Seki, Subrina Jesmin, Majedul Islam, Yoshiyasu Ogura, Masami Oki, Nobutake Shimojo, Tanzila Khatun, Hideaki Sakuramoto, Satoru Kawano and Taro Mizutani
  
  Aim: Myocardial dysfunction is one of the complications associated with sepsis during its (sepsis) pathogenesis. To date, very few studies have investigated whether angiogenic factors in the heart, such as vascular endothelial growth factor (VEGF) and components of its signaling system are involved in myocardial dysfunction during the early phases of sepsis. Therefore, the present study aims to examine: 1) the expression pattern of VEGF and its signaling molecules in the heart during the early hours of LPS-induced sepsis and 2) whether landiolol hydrochloride, an ultrashort-acting beta- blocker, can ameliorate alterations in the expression of cardiac VEGF signaling system components in the rats under these (sepsis) conditions. Method: Eight (8)-week-old male Wistar rats were administered for three hours with either LPS only once, or continuous.. View More»
  DOI: 10.4172/2329-6925.1000193

  Abstract PDF