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Tamimi Yahya
Tamimi Yahya
College of Medicine & Health Sciences,
Muscat
Syria
Publications
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Research Article
Downstream Signaling of the Sos Gene is Not Required during the Pathogenesis of Cancer Cells Bearing KRAS and BRAF Mutations
Author(s): Tamimi Yahya, Al Busaidi Aisha, Gupta Ishita and AL Moundhri Mansour Tamimi Yahya, Al Busaidi Aisha, Gupta Ishita and AL Moundhri Mansour
The Braf/Ras-MAPK is a relevant signal transduction pathway involved in several processes of the cell cycle through activation by interacting with several growth factors and commonly mutated in several cancers. The Sos-1 and Sos-2 (Son of sevenless homolog-1/2) guanine nucleotide exchange factors play a key role in regulating the Ras protein to enable downstream pathway activation. In this study, we investigated the effect of Sos1 proteins on the regulation of the MAPK pathway in the presence and absence of KRAS and BRAF mutations, by monitoring the expression of the downstream proteins, MEK and ERK and their related phosphorylation forms. Our results revealed that knockdown of the Sos1 protein in cells harboring (G13D) and (G464V) mutations within KRAS and BRAF genes respectively did not affect the activation of the MAPK pathway. In contrast, cells with wild-type KRAS and BRAF exhibi.. View More»
DOI: 10.4172/2157-2518.1000240