Journal of Carcinogenesis & Mutagenesis

Takahiro Uotani

Publications

• Research Article
  False Sero-Negative Results for Helicobacter Pylori Infection Indicate Increased Risk of Severe Atrophic Gastritis in Japanese Patients
  Author(s): Hitomi Ichikawa, Mitsushige Sugimoto, Mihoko Yamade, Takahiro Uotani, Shu Sahara, Takuma Kagami, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima and Takahisa Furuta Hitomi Ichikawa, Mitsushige Sugimoto, Mihoko Yamade, Takahiro Uotani, Shu Sahara, Takuma Kagami, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima and Takahisa Furuta
  
  Background/objective: H. pylori infection is commonly diagnosed using an anti-H. pylori IgG antibody test. However, a proportion of results are falsely sero-negative. We investigated characteristics of patients falsely seronegative for H. pylori in relation to gastric atrophy. Methods: H. pylori infection (Hp+ or Hp-) was determined based on culture test, rapid urease test (RUT), and polymerase chain reaction (PCR) test in 280 outpatients. Anti-H. pylori antibody titers ≥ 10 U/ml were diagnosed as sero-positive for H. pylori (IgG+), while those <10 U/ml were sero-negative (IgG-). Serum pepsinogen (PG) I/PG II ratios were calculated as a serological marker of gastric atrophy. Endoscopic gastric mucosal atrophy was also assessed according to the Kimura-Takemoto classification system. Results:.. View More»
  DOI: 10.4172/2157-2518.1000192

  Abstract PDF