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Taha Nazir
Taha Nazir
Chemical Pathology & Molecular Biology Research Group, University Medical & Diagnostic Centre,
Sargodha,40100,
Pakistan
Publications
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Research Article
Designing, Development and Formulation of Mouth Disintegrating Telmisartan Tablet with Extended Release Profile Using Response Surface Methodology
Author(s): Muhammad Abdullah Akram, Taha Nazir, Nida Taha, Adeel Adil, Muhammad Sarfraz and Saeedur Rasheed NazirMuhammad Abdullah Akram, Taha Nazir, Nida Taha, Adeel Adil, Muhammad Sarfraz and Saeedur Rasheed Nazir
The Mouth Disintegrating Tablets (MDT’s) is continuously growing in clinical practice. The pharmaceuticals researchers are exploring the formulations for extended release dosage form with optimal therapeutic benefits. Hence, we aimed this study to develop the mouth disintegrating telmisartan tablet with extended release profile using response surface methodology. Mouth Disintegrating Extended Release Tablets (MDERT’s) was prepared with the intention of obtaining immediate as well as sustain therapeutic effect. The MDERT’s characterized with different determinants. The results were tabulated to illustrate the drug release curves of all 6 formulations upto 12 hrs, DSC spectra of Telmisartan, Kyron T134134, Primogel, Telmisartan + Kyron T134134 + Primogel, Chitosan, CMC and different excepients. The response surface models were developed for disintegration time, wetting.. View More»
DOI: 10.4172/jbb.1000250