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Sutapa Mukherjee
Sutapa Mukherjee
India
Publications
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Research Article
Sulforaphane Inhibits Metastatic Events in Breast Cancer Cells through Genetic and Epigenetic Regulation
Author(s): Madhumita Roy, Ruma Sarkar, Sutapa Mukherjee, Apurba Mukherjee and Jaydip BiswasMadhumita Roy, Ruma Sarkar, Sutapa Mukherjee, Apurba Mukherjee and Jaydip Biswas
Metastasis is a deadly event in carcinogenesis, which is regulated both genetically as well as epigenetically. Regulation of key molecules involved in this phenomenon could be a promising strategy in cancer control. The epigenetic enzyme HDAC6 along with telomerase and HSP90, two genetic markers of carcinogenesis are implicated in the metastatic pathway. Therefore, modulation of these markers may aid in prevention of spread of cancer to distant parts. Plant derived molecules are apparently nontoxic and stud with anticancer activities. Present study aims to investigate the effect of sulforaphane (Sfn), an organosulfur compound on these markers, which might be helpful in inhibition of metastasis. It was observed that sulforaphane significantly inhibited HDAC6 expression, both at protein and genetic level in metastatic breast cancer cell MDA-MB-231. Inhibition of HDAC.. View More»
DOI: 10.4172/2157-2518.1000231