Sushil Kabra
India
Research Article
Scrub Typhus and Leptospirosis: The fallacy of Diagnosing with IgM Enzyme Linked Immunosorbant Assay
Author(s): Nitin Gupta, Rama Chaudhry, Bijay Mirdha, Bimal Das, Lalit Dar, Sushil Kabra, Rakesh Lodha, Aparajit Dey, Rita Sood, Naveet Wig and Vishnubhatla Sreenivas
Nitin Gupta, Rama Chaudhry, Bijay Mirdha, Bimal Das, Lalit Dar, Sushil Kabra, Rakesh Lodha, Aparajit Dey, Rita Sood, Naveet Wig and Vishnubhatla Sreenivas
Introduction: Leptospirosis and scrub typhus are important causes of acute febrile illness in India. IgM Enzyme Linked Immunosorbant Assay (ELISA) is the most common diagnostic modality used for their diagnosis. The common epidemiology of both the diseases creates an opportunity of dual infections with these diseases. Therefore, the objective of the study was to detect and evaluate the cases of serological and molecular dual infections.
Methodology: A cross-sectional diagnostic study from October 2013 to October 2015 was conducted on 258 patients with acute febrile illness. All the samples were subjected to IgM ELISA for scrub typhus and leptospirosis. The samples that were positive for both scrub typhus and leptospirosis were subjected to serological tests for other infections. They were also subjected to PCR assays to find out the cases of.. View More»
DOI:
10.4172/1948-5948.1000265