Journal of Nanomedicine & Nanotechnology

Suresh Chandra Pandey

Publications

• Research Article
  Preparation and Evaluation of Hydrogel Nanoparticles as Drug Delivery System
  Author(s): Rajveer Kaur, Vishal Kumar Gupta and Suresh Chandra PandeyRajveer Kaur, Vishal Kumar Gupta and Suresh Chandra Pandey
  
  Hydrogel nanoparticles (NPs) can be used for colon drug delivery, utilizing Methotrexate (MTX) as a model drug. MTX loaded hydrogel NPs were prepared using Poly-acrylamide-grafted- gum ghatti (PAAm-g-Gg), which is pH sensitive. PAAm-g-Gg was synthesized by free radical polymerization. MTX loaded hydrogel NPs was prepared from PAAm-g-Gg by using nanoemulsification polymer crosslinking method. FT-IR and DSC studies of the prepared NPs indicated no chemical change of MTX in the hydrogel NPs. The prepared hydrogel NPs showed mean diameters in the range of 238 ± 0.57 nm to 1064 ± 0.99 nm. The encapsulation efficiency of the drug was found to be 39.11% to 48.84%. The suitability of the polyacrylamide grafted gum ghatti hydrogel NPs for the release of Methotrexate was studied by in vitro release at pH 1.2 and 7.4. It was observed that, there was no .. View More»
  DOI: 10.4172/2157-7439.1000526

  Abstract PDF