Pharmaceutica Analytica Acta

Sunil Reddy

Publications

• Research Article
  Enantiomeric Separation and Determination of Stereospecific Drug Release from Marketed Racemic Amlodipine Besylate Tablets by HPLC
  Author(s): Jagan Mohan Somagoni, Sunil Reddy, Someshwar Koorelli, Sarangapani Manda and Madhusudan Rao YamsaniJagan Mohan Somagoni, Sunil Reddy, Someshwar Koorelli, Sarangapani Manda and Madhusudan Rao Yamsani
  
  The objective of carrying out this research work was to investigate the effect of chirality on the stereospecific dissolution of amlodipine from various marketed racemic amlodipine besylate tablets. Amlodipine is a calcium ion influx inhibitor which is used in the treatment of hypertension and angina. In this study dissolution of various marketed tablets was performed using USP type II apparatus in 0.1 N HCl at 75 rpm with temperature being maintained at 37±0.5 o C. Chromatographic separation of amlodipine enantiomers was performed using HPLC equipped with UV-Visible detector using Chiral AGP column (100 x 4.6 mm I.D., 5μ particle size). There was no significant difference between the cumulative drug release profiles of S and R enantiomers (p>0.05) in 16 out of 20 marketed racemic amlodipine besylate tablets except for amlong, stamlo-5, amlop.. View More»
  DOI: 10.4172/2153-2435.1000129

  Abstract PDF