Journal of Aquaculture Research & Development

Sudhanshu Shekhar

Publications

• Review Article
  Role of PmRab7 Regulation in WSSV Infection and Functional Validation of Small Molecule as PmRab7 GTPase Inhibitor
  Author(s): Amrendra Kumar, Sudhanshu Shekhar and Saravanakumar A* Amrendra Kumar, Sudhanshu Shekhar and Saravanakumar A*
  
  White Spot Syndrome (WSS) is a viral disease has extensive threatened the shrimp farming industries. It is caused by White spot syndrome baculovirus (WSSB). The shrimps (P. monodon and L. vannamei) are unable to defend themselves by “nonself” materials and pathogen, due to less define adaptive immune response. Therefore, the present work was taken on priority to study the regulation of PmRab7 transcript, which might be a receptor for WSSV (vP28) after implication of small molecule inhibitor. Total 70 GTPase small molecules were screened initially, against the 3D structure of PmRab7. Among all, the CID 1067700 molecule was selected for molecular docking (IFD) with PmRab7 in presence of GTP, GDP and Mg++. Furthermore, a small molecule was fed in feed formulation to P. monodon and transcriptional regulation of PmRab7 was relatively quantified against IFN-α as housekeepi.. View More»
  DOI: 10.4172/2155-9546.1000511

  Abstract PDF