Journal of Bioequivalence & Bioavailability

Sudhakar Akul Yakkanti

Publications

• Research Article
  Resveratrol Enhances the Bioavailability of Fexofenadine in Healthy Human Male Volunteers: Involvement of P-Glycoprotein Inhibition
  Author(s): Satish Kumar Bedada, Sudhakar Akul Yakkanti and Prasad NeeratiSatish Kumar Bedada, Sudhakar Akul Yakkanti and Prasad Neerati
  
  Objective: The purpose of the present study was to assess the influence ofresveratrol onP-glycoprotein mediated drug disposition in humans using fexofenadine as a P-glycoprotein substrate. Methods: A non-blinded, an open label crossover study was conducted in twelve healthy male volunteers aged between 26 and 31 years. A single dose of fexofenadine hydrochloride 120 mg was given to volunteers during control phase and treatment phases. A single dose of resveratrol 500 mg was given to volunteers once daily for period of 10 days. The blood samples were collected at predetermined time intervals during control and treatment phases. The plasma samples containing fexofenadine hydrochloridewere analyzed by LC-MS/MS. The pharmacokinetic parameters were computed by non-compartmental method and the mean pharmacokinetic parameter differences during control and treatment phases were assessed. Resu.. View More»
  DOI: 10.4172/jbb.10000198

  Abstract PDF